Kobe 0065

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2302

CAS [436133-68-5]

MF C15H11ClF3N5O4S
MW 449.79

  • Purity: 99%
  • Soluble in DMSO

Kobe 0065


Orally active RAS inhibitor with selectivity for HRAS (Ki value of 46 ± 13 μM ) that effectively inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-rasG12V–transformed NIH 3T3 cells. This results in down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Kobe 0065 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.
Size Unit Price Stock
10 mg €70.00 In Stock
50 mg €210.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €100.00 In Stock
2 x 50 mg €300.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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