Your cart

There are no items in your shopping cart

Kobe 0065

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2302

CAS [436133-68-5]

MF C15H11ClF3N5O4S
MW 449.79

  • Purity: 99%
  • Soluble in DMSO

Kobe 0065

Description

Orally active RAS inhibitor with selectivity for HRAS (Ki value of 46 ± 13 μM ) that effectively inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-rasG12V–transformed NIH 3T3 cells. This results in down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Kobe 0065 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.
Order
Size Unit Price Stock
10 mg €70.00 In Stock
50 mg €210.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €100.00 In Stock
2 x 50 mg €300.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1578 NSC 23766 Rac1 inhibitor €110.00
1639 YM155 Survivin suppressant €95.00
1794 LB 42708 Inhibitor of farnesyltransferase (FTase) €95.00
1825 Erastin VDAC2 modulator €90.00
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
1985 Xevinapant Antagonist of Inhibitor of apoptosis proteins (IAPs) €145.00
2017 ML 210 Chemical probe that selectively kills cells induced to express mutant RAS €115.00
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €70.00
2165 S 12 Survivin inhibitor €105.00
2176 LCS-1 Inhibits SOD1 enzymatic activity. Lead compound for lung cancer therapeutics €85.00
2007 HA 14-1 Bcl-2 inhibitor and apoptosis inducer of tumor cells €75.00
2284 Deltarasin trihydrochloride Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction. €120.00
2300 TIC10 active isomer Small molecule that transcriptionally induces TRAIL €120.00
2184 CID 1067700 First inhibitor of Rab7 GTPase €125.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
2293 Ferrostatin 1 Potent inhibitor of erastin-induced ferroptosis €85.00
2351 EHop 016 Rac GTPase inhibitor specific for Rac1 and Rac3 €85.00
2396 RBC 8 Inhibitor of the RAS-like small GTPases RalA and RalB €105.00
2397 BQU 57 Inhibitor of the RAS-like small GTPases RalA and RalB €125.00
2438 Cuspin-1 Upregulator of the Survival of Motor Neuron protein (SMN) by Ras signaling activation €95.00
2611 APS-2-79 Inhibitor of KSR and oncogenic Ras signaling €90.00
2829 Fendiline hydrochloride KRAS inhibitor; Ca2+ channel blocker (L-type voltage gated) €50.00
3714 BCL-201 dihydrochloride BH3-mimetic inhibitor of BCL-2 protein Inquire
3814 AZD4320 BH3-mimetic inhibitor of BCL-2 protein Inquire
3821 ABT-263 Potent, selective and orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins Inquire

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...