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10 mg

$77.00

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Kobe 0065

Name: Kobe 0065
SKU: 2302

Axon 2302

CAS: 436133-68-5

Purity: 99%

Soluble in DMSO

MF: C15H11ClF3N5O4S
MW: 449.79

Description

Orally active RAS inhibitor with selectivity for HRAS (Ki value of 46 ± 13 μM ) that effectively inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-rasG12V–transformed NIH 3T3 cells. This results in down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Kobe 0065 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

HRAS

Parent CAS No.	436133-68-5
Chemical Name	N-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazinecarbothioamide
SMILES	N(C(=S)NC1=CC=C(C)C(Cl)=C1)NC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O
MFCD	N.A.
InChi	InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
InChiKey	KSJVAYBCXSURMQ-UHFFFAOYSA-N
CID	3827663
Short Description	HRAS inhibitor

Kobe 0065 CAS 436133-68-5 Axon 2302 HRAS inhibitor Axon Ligands Axon Medchem Supplier Axon2302 Kobe0065 HRAS RAS apoptosis MEK ERK antitumor Vendor

References

F. Shima et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. PNAS U.S.A. 2013, 110, 8182-8187.

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Kobe 0065

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