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Wnt-C59

 - C59
Axon 2287
CAS:  1243243-89-1
Purity:  98%
  • Soluble in DMSO
  • MF:  C25H21N3O
  • MW:  379.45

Description

Nanomolar and orally available inhibitor of mammalian PORCN acyltransferase activity (IC50 value of 74 pM) that blocks activation of all evaluated human Wnts ( Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity).The tumor growth inhibition of Wnt-C59 in MMTV-WNT1 transgenic mice is associated with decreased Wnt/β-catenin signaling in tumors.

More Information

Certificate of Analysis

Material Safety Data Sheet

Parent CAS No. 1243243-89-1
Chemical Name 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
SMILES C1(CC(NC2=CC=C(C3=CC=CN=C3)C=C2)=O)=CC=C(C2C=CN=C(C)C=2)C=C1
MFCD N.A.
InChi InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
InChiKey KHZOJCQBHJUJFY-UHFFFAOYSA-N
CID 57519544
Short Description Porcn inhibitor

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