SCH 529074

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2244

CAS [922150-11-6]

MF C31H36Cl2N6
MW 563.56

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

SCH 529074

Description

Small molecule activator of mutant p53 which binds p53 DNA binding domain (DBD; Kd value 1-2 μM). SCH 529074 restores growth-suppressive function to mutant p53 (R273H and the structural mutant R249S) by acting as a chaperone and interrupts HDM2-mediated ubiquitination of wild type p53.

M. Demma et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination (...). J. Biol. Chem. 2010, 285, 10198-10212.

F. Essmann et al. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br. J. Pharmacol. 2012, 165, 328-344.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1

Small molecule activator of mutant p53.

Chemical name

N1-(2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine

Parent CAS No.

[922150-11-6]

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5 mg	€120.00	In Stock
25 mg	€420.00	In Stock

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2 x 25 mg	€700.00	In Stock

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SCH 529074

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SCH 529074

Description

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