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SCH 529074
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C31H36Cl2N6
- MW: 563.56
Description
More Information
| Parent CAS No. | 922150-11-6 |
|---|---|
| Chemical Name | N1-(2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine |
| SMILES | C(N(C)C)CCNC1=C2C(=NC(CN3CCN(C(C4=CC=C(Cl)C=C4)C4=CC=C(Cl)C=C4)CC3)=N1)C=CC=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C31H36Cl2N6/c1-37(2)17-5-16-34-31-27-6-3-4-7-28(27)35-29(36-31)22-38-18-20-39(21-19-38)30(23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h3-4,6-15,30H,5,16-22H2,1-2H3,(H,34,35,36) |
| InChiKey | NCAJLQDPTZBGJV-UHFFFAOYSA-N |
| CID | 12001922 |
| Short Description | p53 activator |
References
- M. Demma et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination (...). J. Biol. Chem. 2010, 285, 10198-10212.
- F. Essmann et al. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br. J. Pharmacol. 2012, 165, 328-344.
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