iCRT14 - CRT Inhibitor iCRT14

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2135

CAS [677331-12-3]

MF C21H17N3O2S
MW 375.44

  • Purity: 98%
  • Soluble in DMSO



Small-molecule inhibitor of the Wnt/wingless signaling pathway (IC50 value 40 nM in a Wnt responsive STF16-luc reporter assay) that antagonizes the transcriptional function of nuclear β-catenin, and inhibits direct interactions between β-cat and TCF4. iCRT 14 exhibits specific cytotoxicity towards human colon tumor biopsy cultures as well as colon cancer cell lines that exhibit deregulated Wnt signaling. Similar mode of action as iCRT5 (Axon 2133)

Size Unit Price Stock
10 mg €135.00 In Stock
50 mg €535.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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