iCRT5 - CRT Inhibitor iCRT5

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2133

CAS [18623-44-4]

MF C16H17NO5S2
MW 367.44

  • Purity: 99%
  • Soluble in DMSO

iCRT5

Description

Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor, with IC50 value of 18 nM for Wnt responsive STF16 luciferase (STF16-Luc). iCRT5 acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin, while displaying minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling
β-Catenin-responsive transcription (CRT) inhibitor

Chemical name

4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid

Parent CAS No.

[18623-44-4]

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10 mg €80.00 In Stock
50 mg €260.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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