CGP 77675

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2097

CAS [234772-64-6]

MF C26H29N5O2
MW 443.54

  • Purity: 98%
  • Soluble in 0.1N HCl(aq) and DMSO

CGP 77675

Description

Potent and selective Src family kinase (SFK) inhibitor; CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i, Axon 2130) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos.

*Promotion: CGP 77675 is also part of Inhibitor Set(s):

Axon 2130

KEYWORDS: CGP 77675 | supplier | Src inhibitor | CGP77675 | CGP-77675 | CAS [234772-64-6] | Non Selective | SRC | Inhibitor | Enzymes

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5 mg €90.00 In Stock
25 mg €330.00 In Stock
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2 x 5 mg €140.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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