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Linezolid
- Zyvox - PNU 100766 - U 100766
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C16H20FN3O4
- MW: 337.35
Description
More Information
| Parent CAS No. | 165800-03-3 |
|---|---|
| Chemical Name | (S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide |
| extra_info | . |
| SMILES | C(NC[C@@H]1OC(=O)N(C2=CC=C(N3CCOCC3)C(F)=C2)C1)(=O)C |&1:3,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1 |
| InChiKey | TYZROVQLWOKYKF-ZDUSSCGKSA-N |
| CID | 441401 |
| Short Description | Antibiotic |
References
- SJ Brickner et al. Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J. Med. Chem. 2008, 51(7), 1981-1990.
- MR Barbachyn, CW Ford. Oxazolidinone structure-activity relationships leading to linezolid. Angew. Chem. Int. Ed. Engl. 2003, 42(18), 2010-23.
- SJ Brickner et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. J. Med. Chem. 1996, 39(3), 673-9.
- U Patel et al. Oxazolidinones mechanism of action: inhibition of the first peptide bond formation. J. Biol. Chem. 2001, 276(40), 37199-205.
- CE Barry and JS Blanchard. The Chemical Biology of New Drugs in Development for Tuberculosis. Curr. Opin. Chem. Biol. 2010, 14(4), 456–466.
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