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Tedizolid phosphate
- TR701 - Torezolid phosphate - DA7218
Axon 3312
CAS:
856867-55-5
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C17H16FN6O6P
- MW: 450.32
Description
Tedizolid phosphate is an oxazolidinone prodrug of Tedizolid, which is a highly potent antibacterial agent displaying good activity against important Gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA) and some linezolid-resistant staphylococci.
More Information
| Parent CAS No. | 856867-55-5 |
|---|---|
| Chemical Name | (R)-(3-(3-Fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate |
| SMILES | N1C(C2=NN(C)N=N2)=CC=C(C2C=CC(N3C(=O)O[C@@]([H])(COP(=O)(O)O)C3)=CC=2F)C=1 |&1:19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16FN6O6P/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(30-17(24)25)9-29-31(26,27)28/h2-7,12H,8-9H2,1H3,(H2,26,27,28)/t12-/m1/s1 |
| InChiKey | QCGUSIANLFXSGE-GFCCVEGCSA-N |
| CID | 11476460 |
| Short Description | Antibiotic |
References
- WB Im et al. Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. Eur J Med Chem. 2011 Apr;46(4):1027-39.
- SD Brown et al. Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. Antimicrob Agents Chemother. 2010 May;54(5):2063-9.
- C Foti et al. Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects. Molecules. 2021 Jul 14;26(14):4280.
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