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SU 6668
- TSU 68 - Orantinib
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C18H18N2O3
- MW: 310.35
Description
More Information
| Parent CAS No. | 252916-29-3 |
|---|---|
| Chemical Name | 3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid |
| SMILES | N1C(/C=C2/C3=C(NC/2=O)C=CC=C3)=C(C)C(CCC(O)=O)=C1C |
| MFCD | N.A. |
| InChi | InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9- |
| InChiKey | NHFDRBXTEDBWCZ-ZROIWOOFSA-N |
| CID | 5329099 |
| Short Description | RTK inhibitor |
References
- L Sun et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999, 42(25), 5120-5130.
- AD Laird et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 2000, 60(15), 4152-4160.
- M Toi et al. A multicenter phase II study of TSU-68, an oral multiple tyrosine kinase inhibitor, in combination with docetaxel in metastatic breast cancer patients with anthracycline resistance. Breast Cancer. 2014, 21(1), 20-27.
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