Nutlin-3a - (-)-Nutlin-3

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1880

CAS [675576-98-4]

MF C30H30Cl2N4O4
MW 581.49

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO



Nutlin-3a is an antagonist or inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53.

*Note: Nutlin-3a (Axon 1880) is the 150-fold more potent (-)-enantiomer of Nutlin-3 (Axon 1585), in comparision with the opposite (+)-enantiomer Nutlin-3b (Axon 1881). Presently, much attention has been given to Nutlin-3a and its absolute stereo-assignment is now known.

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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