Brivanib alaninate - BMS 582664

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1864

CAS [649735-63-7]

MF C22H24FN5O4
MW 441.46

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

Brivanib alaninate


Brivalib alaninate (BMS 582664) is the orally active prodrug of BMS 540215 (Axon 1850). Brivanib alaninate hydrolyzes in vivo quickly to BMS 540215, which is a potent and ATP-competitive VEGFR inhibitor with IC50 of 25, 380 and 10 nM for VEGFR2, -1 and -3 respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM

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2 mg €105.00 In Stock
5 mg €185.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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