Brivanib alaninate - BMS 582664

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1864

CAS [649735-63-7]

MF C22H24FN5O4
MW 441.46

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

Brivanib alaninate

Description

Brivalib alaninate (BMS 582664) is the orally active prodrug of BMS 540215 (Axon 1850). Brivanib alaninate hydrolyzes in vivo quickly to BMS 540215, which is a potent and ATP-competitive VEGFR inhibitor with IC50 of 25, 380 and 10 nM for VEGFR2, -1 and -3 respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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