BMS 540215 - Brivanib

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1850

CAS [649735-46-6]

MF C19H19FN4O3
MW 370.38

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO

BMS 540215

Description

Potent and ATP-competitive inhibitor of VEGF; it inhibits VEGFR2, -1 and -3 with IC50 of 25, 380 and 10 nM respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM. BMS 540215 is the active component of its prodrug, Brivalib alaninate (BMS 582664, Axon 1864), which hydrolyzes to BMS 540215 in vivo quickly

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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