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EGFR Inhibitor [879127-07-8]
- EGFR Inhibitor 324674
- Soluble in DMSO
- MF: C21H18F3N5O
- MW: 413.4
Description
EGFR Inhibitor [879127-07-8] is a potent, cell-permeable and irreversible EGFR tyrosine kinase inhibitor with nanomolar activity.
EGFR signaling regulates proliferation, survival and differentiation and is frequently altered in cancer models. EGFR Inhibitor [879127-07-8] is useful for studying irreversible EGFR blockade and receptor tyrosine kinase pathway dependence.
Key Features
- Irreversible EGFR tyrosine kinase inhibitor
- Nanomolar-range inhibitory activity
- Cell-permeable receptor tyrosine kinase tool
- Relevant to oncogenic EGFR signaling models
Applications
- EGFR kinase assay development
- Cancer cell signaling research
- Covalent inhibitor mechanism studies
- RTK pathway inhibition and resistance models
More Information
| Parent CAS No. | 879127-07-8 |
|---|---|
| Chemical Name | N-(3-(6-(3-(trifluoromethyl)phenylamino)pyrimidin-4-ylamino)phenyl)cyclopropanecarboxamide |
| SMILES | C1(NC(=O)C2CC2)C=C(NC2C=C(NC3C=C(C(F)(F)F)C=CC=3)N=CN=2)C=CC=1 |
| MFCD | MFCD13191284 |
| InChi | InChI=1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(9-14)27-18-11-19(26-12-25-18)28-16-5-2-6-17(10-16)29-20(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,29,30)(H2,25,26,27,28) |
| InChiKey | YOHYSYJDKVYCJI-UHFFFAOYSA-N |
| CID | 9549299 |
| Short Description | EGFR inhibitor |
References
- Q Zhang et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J. Am. Chem. Soc. 2006, 128(7), 2182-2183.
- K Okamoto et al. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Res. 2010, 70(24), 10402-10410.
- Z Yu et al. Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. Biochem. Biophys. Res. Commun. 2011, 411(4), 751-756.
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