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Tivozanib
- AV 951 - KRN 951
- Moderately soluble in DMSO
- MF: C22H19ClN4O5
- MW: 454.86
Description
More Information
| Parent CAS No. | 475108-18-0 |
|---|---|
| Chemical Name | 1-(2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(5-methylisoxazol-3-yl)urea |
| SMILES | C1(OC)C=C2C(OC3C=CC(NC(=O)NC4=NOC(C)=C4)=C(Cl)C=3)=CC=NC2=CC=1OC |
| MFCD | MFCD15146788 |
| InChi | InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) |
| InChiKey | SPMVMDHWKHCIDT-UHFFFAOYSA-N |
| CID | 9911830 |
| Short Description | VEGFR inhibitor |
References
- K Nakamura et al. KRN951, a Highly Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Has Antitumor Activities and Affects Functional Vascular Properties. Cancer Res. 2006, 66(18), 9134-9142.
- Eri Taguchi et al. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci. 2008, 99(3), 623.
- C Campas et al. Tivozanib. Drugs Fut. 2009, 34(10), 793.
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