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FR 180204
- Soluble in DMSO
- MF: C18H13N7
- MW: 327.34
Description
FR 180204 is a selective, cell-permeable and ATP-competitive ERK1/ERK2 inhibitor with Ki values of 0.31 μM for ERK1 and 0.14 μM for ERK2.
ERK1/2 are terminal kinases in the RAS-RAF-MEK-ERK pathway and regulate proliferation, differentiation and transcriptional responses. FR 180204 is used to dissect ERK-dependent signaling and AP-1 pathway activation.
Key Features
- ATP-competitive inhibitor of ERK1 and ERK2
- Ki: 0.31 μM for ERK1 and 0.14 μM for ERK2
- Approximately 30-fold selective over p38α MAPK
- Inhibits TGFβ-induced AP-1 activation
Applications
- ERK/MAPK pathway research
- AP-1 transcriptional response assays
- Growth factor signaling studies
- Kinase selectivity profiling
More Information
| Parent CAS No. | 865362-74-9 |
|---|---|
| Chemical Name | 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-7H-pyrazolo[3,4-c]pyridazin-5-amine |
| SMILES | C1(C(C2N=NC3NN=C(N)C=3C=2)=C2C=CC=CN2N=1)C1=CC=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23) |
| InChiKey | XVECMUKVOMUNLE-UHFFFAOYSA-N |
| CID | 11493598 |
| Short Description | ERK inhibitor |
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