FR 180204

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1694

CAS [865362-74-9]

MF C18H13N7
MW 327.34

Purity: 99%
Soluble in DMSO

FR 180204

Description

Selective, cell permeable and ATP-competitive ERK inhibitor; 30-fold selective on ERK over p38α MAPK; FR180204 was shown to inhibit ERK1 (Ki=0.31μM), ERK2 (Ki=0.14 μM) and TGFβ-induced AP-1 activation

M Ohori et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005, 336(1), 357-363.

M Ohori. ERK inhibitors as a potential new therapy for rheumatoid arthritis. Drug News Perspect. 2008, 21(5), 245-250.

ERK inhibitor; AP-1 inhibitor

Chemical name

3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-7H-pyrazolo[3,4-c]pyridazin-5-amine

Parent CAS No.

[865362-74-9]

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FR 180204

Description

Chemical name

Parent CAS No.

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FR 180204

Description

Chemical name

Parent CAS No.

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