SCIO 469 - Talmapimod

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1671

CAS [309913-83-5]

MF C27H30ClFN4O3
MW 513.00

Purity: 98%
Soluble in DMSO

SCIO 469

Description

Orally available and selective inhibitor of p38 mitogen-activated protein (MAP) kinase (MAPK), with a 10-fold selectivity for p38α over p38β and 2000-fold over 20 other kinases; potential agent with immunomodulating, anti-inflammatory and antineoplastic activities

SN Nikas and AA Drosos. SCIO-469 Scios Inc. Curr Opin Investig Drugs. 2004, 5(11), 1205-1212.

T Navas et al. The p38 MAPK inhibitor SCIO-469 enhances the apoptotic and anti-proliferative effects of proteasome inhibitors MG132 and PS341 (Velcade) in multiple myeloma cells. Proc. Amer. Assoc. Cancer Res, 2004, Vol. Abs. #3350.

MAPK inhibitor (p38 specific)

Chemical name

2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide

Parent CAS No.

[309913-83-5]

Order

Size	Unit Price	Stock
5 mg	€120.00	In Stock
25 mg	€400.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1122	SL 327	MEK1 and MEK2 inhibitor	€80.00
1223	PD98059	MEK inhibitor	€80.00
1357	SD 169	MAPK inhibitor (p38α specific)	€60.00
1358	BIRB 796	MAPK inhibitor (p38 specific)	€65.00
1363	SB 203580	MAPK inhibitor (p38 specific)	€95.00
1364	SB 202190	MAPK inhibitor (p38 specific)	€95.00
1365	PD169316	MAPK inhibitor (p38 specific)	€95.00
1368	PD184352	MEK 1 inhibitor	€80.00
1408	PD0325901	MEK1 and MEK2 inhibitor	€50.00
1465	SB 203580 hydrochloride	MAPK inhibitor (p38 specific)	€70.00
1516	AZD6244	MEK1 and MEK2 inhibitor	€60.00
1694	FR 180204	ERK inhibitor; AP-1 inhibitor	€95.00
1761	GSK 1120212	MEK1 and MEK2 inhibitor	€70.00
1809	BIX 02189	MEK5 inhibitor; ERK5 inhibitor	€110.00
1811	VX 745	Inhibitor of p38α MAP kinase	€90.00
1837	PH 797804	Inhibitor of p38α MAPK	€115.00
1846	XMD 8-92	BMK1 inhibitor; ERK5 inhibitor	€70.00
1895	LY 2228820	Inhibitor of p38 MAPK	€105.00
1999	AZD8330	MEK 1 inhibitor	€105.00
2366	NG 25 trihydrochloride	Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK)	€75.00
2318	FC 99 hydrochloride	Inhibitor of TLR3 expression and inflammatory responses.	€95.00
2444	SB 706504	Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes.	€125.00
2520	U 0126	Non-competitive inhibitor of MEK1/2 and protects brain in stroke models	€90.00
2656	CRT0066854	Selective ATP-competitive inhibitor of the atypical PKC isoenzymes	€135.00
2786	(±)-PH 797804	Inhibitor of p38α MAPK	€115.00
2856	BMS 582949	Inhibitor of p38α MAPK	€155.00
3183	SR-318	Highly potent and selective type-II p38 α/β inhibitor	€120.00
3440	MK2 inhibitor III	Potent and selective MK-2 inhibitor	€120.00
1621	XMD 8-92 trifluoroacetate	BMK1 inhibitor; ERK5 inhibitor	€70.00
3620	MAPK13 inhibitor compound 61	MAPK13 inhibitor (p38δ specific)	€140.00
4219	VX-702	Orally bioavailable p38 MAP kinase inhibitor	Inquire

Customer Support

Customer Services

About Axon Medchem

Contact Us

SCIO 469 - Talmapimod

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

SCIO 469 - Talmapimod

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us