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Pelitinib
- EKB 569
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H23ClFN5O2
- MW: 467.92
Description
More Information
| Parent CAS No. | 257933-82-7 |
|---|---|
| Chemical Name | (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide |
| SMILES | C12C=C(C(=CC=1N=CC(C#N)=C2NC1=CC=C(C(Cl)=C1)F)OCC)NC(=O)/C=C/CN(C)C |
| MFCD | MFCD09837868 |
| InChi | InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ |
| InChiKey | WVUNYSQLFKLYNI-AATRIKPKSA-N |
| CID | 6445562 |
| Short Description | ErbB inhibitor |
References
- M Nunes et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an EGFR inhibitor, EKB-569, (...). Mol. Cancer Ther. 2004, 3,21.
- C Erlichman et al. Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J. Clin. Oncol. 2006, 24(15), 2252-2260.
- A Ocaña and E Amir. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions. Cancer Treat Rev. 2009, 5(8), 685-691.
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