JavaScript seems to be disabled in your browser.
You must have JavaScript enabled in your browser to utilize the functionality of this website.

Axon Medchem

All

Home
Products
- Shop By Category
- Featured Products
- Shop By Alphabet
  - A
  - B
  - C
  - D
  - E
  - F
  - G
  - H
  - I
  - J
  - K
  - L
  - M
  - N
  - O
  - P
  - Q
  - R
  - S
  - T
  - U
  - V
  - W
  - X
  - Y
  - Z
  - #
Support
- - Customer Support
  - Customer Services
Contact
- About Axon Medchem
- Contact Us

OSI 420 - Erlotinib, 6-O-Desmethyl-

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1632

CAS [183321-86-0]

MF C21H21N3O4
MW 379.41

Purity: 98%
Soluble in DMSO

OSI 420

Description

An active O-desmethyl metabolite of Erlotinib (Axon 1128), which inhibits EGFR tyrosine kinase; precursor of [¹¹C]-labelled Erlotinib for PET study

A Broniscer et al. Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin. Cancer Res. 2007, 13(5), 1511-1515.

Y Togashi et al. Cerebrospinal Fluid Concentration of Erlotinib and its Active Metabolite OSI-420 in Patients with Central Nervous System Metastases of Non-small Cell Lung Cancer. J. Thoracic Oncol. 2010, 5(7), 950-955.

I. Bahce et al. Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status. Clin. Cancer Res. 2013, 19, 183-193.

NF Smith et al. Modulation of erlotinib pharmacokinetics in mice by a novel cytochromeP450 3A4 inhibitor, BAS 100. Br. J. Cancer 2008, 98, 1630–1632.

AA Memon et al. Positron Emission Tomography (PET) Imaging with [11C]-Labeled Erlotinib: A Micro-PET Study on Mice with Lung Tumor Xenografts. Cancer Res. 2009, 69(3), 873-878.

Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1

EGFR tyrosine kinase inhibitor

Chemical name

2-(4-(3-ethynylphenylamino)-7-(2-methoxyethoxy)quinazolin-6-yloxy)ethanol

Parent CAS No.

[183321-86-0]

Order

Size	Unit Price	Stock
2 mg	€90.00	In Stock
5 mg	€135.00	In Stock

Need more? Bulk Inquiry

Please wait...