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JNJ 26854165 dihydrochloride
- Serdemetan dihydrochloride - 881202-16-0
- Parent CAS: 881202-45-5
- Soluble in water and DMSO
- MF: C21H20N4.2HCl
- MW: 401.33
Description
JNJ 26854165 dihydrochloride (Serdemetan dihydrochloride) is an HDM2/MDM2 pathway inhibitor reported to restore p53-dependent signaling in tumor cell models. JNJ 26854165 dihydrochloride is the water-soluble salt form of JNJ 26854165 (Axon 1538)
MDM2-mediated regulation of p53 controls tumor suppressor activity, cell-cycle arrest and apoptosis. JNJ 26854165 dihydrochloride is useful for studying p53 reactivation pharmacology and stress-response signaling in cancer research models.
Key Features
- HDM2/MDM2 pathway inhibitor
- Activates p53-linked cellular responses
- Reported activity in multiple myeloma and other tumor models
- Useful for tumor suppressor and apoptosis research
Applications
- p53 pathway pharmacology
- HDM2/MDM2 inhibitor studies
- Cancer cell apoptosis assays
- Multiple myeloma and oncology model research
More Information
| Parent CAS No. | 881202-45-5 |
|---|---|
| Chemical Name | N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine dihydrochloride |
| SMILES | Cl.Cl.C1(NCCC2C3=C(NC=2)C=CC=C3)=CC=C(NC2C=CN=CC=2)C=C1 |
| MFCD | MFCD17392585 |
| InChi | InChI=1S/C21H20N4.2ClH/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19;;/h1-8,10-13,15,23-24H,9,14H2,(H,22,25);2*1H |
| InChiKey | DVFXABLZWONTKS-UHFFFAOYSA-N |
| CID | 91826475 |
| Short Description | HDM2 inhibitor |
References
- T. Stühmer et al. A first-in-class HDM2-inhibitor (JNJ-26854165) in phase I development shows potent activity against multiple myeloma (MM) cells in vitro and ex vivo. J Clin Oncol 26: 2008 (May 20 suppl; abstr 14694)
- K Kojima et al. The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias. Mol. Cancer Ther. 2010, 9(9), 2545–2557.
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