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PD0332991 hydrochloride
- Palbociclib hydrochloride
- Parent CAS: 571190-30-2
- Soluble in water
- MF: C24H29N7O2.2HCl
- MW: 520.45
Description
An orally active cyclin-dependent kinase (CDK) inhibitor, specifically targeting on CDK4 and CDK6; a potential agent for the treatment of breast cancer; water soluble hydrochloride salt form, ideal for in vivo experiments. Another salt form, PD0332991 isethionate (Axon 2052) is also available.
Prime Source Information:
The molecule of PD0332991 contains multiple basic nitrogens, which could form 1 to 4 eq HCl salt of PD0332991 and its accurate salt form has been determined by microanalysis and specified on certificate of analysis (COA) of every batch of our samples.
More Information
| Parent CAS No. | 571190-30-2 |
|---|---|
| Chemical Name | 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride |
| extra_info | . |
| SMILES | C1CCCC1N1C2N=C(NC3C=CC(N4CCNCC4)=CN=3)N=CC=2C(C)=C(C(=O)C)C1=O.Cl.Cl |
| MFCD | MFCD11840850 |
| InChi | InChI=1S/C24H29N7O2.2ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);2*1H |
| InChiKey | YORIVNBSTFKZTO-UHFFFAOYSA-N |
| CID | 60167560 |
| Short Description | CDK 4/6 inhibitor |
References
- RL Sutherland and EA Musgrove. CDK inhibitors as potential breast cancer therapeutics: new evidence for enhanced efficacy in ER+ disease. Breast Cancer Res. 2009, 11(6), 112-113.
- RS Finn et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009, 11(5), R77.
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