PD0332991 hydrochloride - Palbociclib hydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1505

CAS [1831842-69-3]

MF C24H29N7O2.2HCl
MW 520.45

Purity: 99%
Soluble in water

PD0332991 hydrochloride

Description

An orally active cyclin-dependent kinase (CDK) inhibitor, specifically targeting on CDK4 and CDK6; a potential agent for the treatment of breast cancer; water soluble hydrochloride salt form, ideal for in vivo experiments. Another salt form, PD0332991 isethionate (Axon 2052) is also available.

Prime Source Information:
The molecule of PD0332991 contains multiple basic nitrogens, which could form 1 to 4 eq HCl salt of PD0332991 and its accurate salt form has been determined by microanalysis and specified on certificate of analysis (COA) of every batch of our samples.

RL Sutherland and EA Musgrove. CDK inhibitors as potential breast cancer therapeutics: new evidence for enhanced efficacy in ER+ disease. Breast Cancer Res. 2009, 11(6), 112-113.

RS Finn et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009, 11(5), R77.

D.W. Fry et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol. Cancer Ther. 2004, 3, 1427-1438.

CDK4 and CDK6 inhibitor

Chemical name

6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride

Parent CAS No.

[571190-30-2]

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5 mg	€80.00	In Stock
25 mg	€240.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€120.00	In Stock
2 x 25 mg	€360.00	In Stock

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PD0332991 hydrochloride - Palbociclib hydrochloride

Description

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Parent CAS No.

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PD0332991 hydrochloride - Palbociclib hydrochloride

Description

Chemical name

Parent CAS No.

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