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Naive Stem Cell 5i inhibitor Set
Set of 5 Inhibitors
SB590885 (Axon 2504)
PD0325901 (Axon 1408)
Y 27632 dihydrochloride (Axon 1683)
WH 4-023 (Axon 2381)
IM-12 (Axon 2511)
(2 mg or 5 mg of each inhibitor)
* Five Inhibitors are in powder form (high purity: 99%).
Ready to be reconstituted freshly to their 10 mM solutions in DMSO respectively.
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Description
A convenient set of five small molecule pathway inhibitors (termed as Naive stem cell 5i inhibitors): - BRAF inhibitor SB590885 (Axon 2504) - MEK inhibitor PD0325901 (Axon 1408) - ROCK inhibitor Y27632 dihydrochloride (Axon 1683) - SRC/LCK inhibitor WH 4-023 (Axon 2381) - GSK3β inhibitor IM-12 (Axon 2511) (*Alternatively, CHIR99021 (Axon 1386) can be used as GSK3β inhibitor. Not included.)
The combination of five inhibitors of MEK, GSK3β, BRAF, ROCK, and SRC, supports the expansion of viable OCT4-ΔPE-GFP+ human pluripotent cells after exogenous transcription factor expression has been removed. Useful tool for the induction and maintenance of human naive stem cell pluripotency.
Read more: Additional Product Information
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More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N.A. |
| MFCD | N.A. |
| Short Description | Stem cell inhibitor set |
References
- TW Theunissen et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell. 2014 Oct 2;15(4):471-87.
- List of publications using PD0325901 (Axon 1408) purchased from Axon Medchem
- List of publications using Y 27632 dihydrochloride (Axon 1683) purchased from Axon Medchem
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