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CP 101606
- Traxoprodil
- Optical Purity: 98% d.e.
- Soluble in water and DMSO
- MF: C20H25NO3
- MW: 327.42
Description
Potent and NR2B selective antagonist of NMDA glutamate receptors.
A water soluble form, CP 101606 mesylate (Axon 1406) is readily available as well.
More Information
| Parent CAS No. | 134234-12-1 |
|---|---|
| Chemical Name | 1-[(1S,2S)-2-Hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-4-phenylpiperidin-4-ol |
| SMILES | C1(C2(O)CCN([C@H]([C@@H](O)C3=CC=C(O)C=C3)C)CC2)C=CC=CC=1 |&1:6,7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1 |
| InChiKey | QEMSVZNTSXPFJA-HNAYVOBHSA-N |
| CID | 219101 |
| Short Description | NR2B antagonist |
References
- K Taniguchi et al. Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br. J. Pharmacol. 1997, 122, 809–812.
- FS. Menniti et al. CP-101,606: An NR2B-Selective NMDA Receptor Antagonist. CNS Drug Rev. 1998, 4(4), 307-322.
- L. Yurkewicz et al. The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. J. Neurotrauma. 2005, 22(12), 1428-43.
- JG Nutt et al. Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and parkinsonist. Mov. Disord. 2008, 23(13), 1860-1866.
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