Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
2639 AMG 232 Potent, selective, and orally bioavailable MDM2-p53 inhibitor €115.00
2500 Apilimod mesylate Cytokine inhibitor; IL-12 and IL-23 inhibitor Inquire
1992 AS 1517499 Potent and selective STAT6 inhibitor €145.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
2132 BAY 11-7082 IKK inhibitor and anti-inflammatory €85.00
1731 BMS 345541 Cell-permeable and selective IKB (IKK) inhibitor €105.00
2489 Brassinin Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity €75.00
1390 BX 795 PDPK1, TBK1 and IKK inhibitor €65.00
2699 CCT251236 HSF1 stress pathway inhibitor  Recently added €145.00
1772 CDDO-Me IKK-2 inhibitor; Inducer of the Nrf2 pathway €85.00
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) €105.00
1977 DMOG Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties €65.00
2568 EML 425 Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) €95.00

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