Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
3069 CCG-222740 Potent and selective Rho/MRTF/SRF transcriptional pathway inhibitor €145.00
2699 CCT251236 HSF1 stress pathway inhibitor €145.00
1772 CDDO-Me IKK-2 inhibitor; Inducer of the Nrf2 pathway €80.00
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
3224 CLK8 CLOCK/BMAL1 interaction inhibitor €160.00
3035 Compound 10

Tool compound targeting the NFAT:AP-1 transcriptional complex on DNA.

€150.00
2841 COTI-2 Reactivator of mutant p53 €125.00
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €95.00
3428 CSF1R inhibitor compound 22 Potent, cellular active and orally bioavailable CSF1R inhibitor €130.00
1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) €105.00
1977 DMOG Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties €65.00
3412 DTHIB Direct and selective HSF1 inhibitor €90.00
2568 EML 425 Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) €95.00
2800 Ensemble Compound 159 Cytokine inhibitor; IL-17A inhibitor Inquire
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00

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