Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
3387 NF-κB Activation Inhibitor IV Potent NF-κB activation inhibitor €90.00
3031 NIC3 Inhibitor of nucleus accumbens-associated protein-1 (NAC1) homodimerization €90.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00
1402 NSC 348884 NPM inhibitor €120.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
1585 Nutlin-3 MDM2 inhibitor (p53 specific) €95.00
1880 Nutlin-3a Inhibitor of MDM2 €95.00
1881 Nutlin-3b Less potent (+)-enantiomer of Nutlin-3 €90.00
2651 OAC2 Oct4 and Nanog activating compound that enhances reprogramming efficiency €60.00
3475 OLT1177 Selective and orally active NLRP3 inflammasome inhibitor  Recently added €70.00
2497 Omaveloxolone Triterpenoid activator of NRF2 and inhibitor of NF-κB €90.00
1651 PHA 408 IKK-2 inhibitor €105.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
3051 Pifithrin-β Inhibitor of p53 protein; Condensation product of Pifithrin-α €95.00
2488 Piperlongumine Natural alkaloid with potent cytotoxic activity €65.00

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