C8 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 2.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.

NMDAR-TRPM4 blocker C19 is available as Axon 3349.

KEYWORDS: C8 | supplier | NMDAR/TRPM4 inhibitor | FMP-A-01 | Brophenexin | CAS [2243506-33-2] | [1353979-43-7] | Glutamate | NMDA | Inhibitor | Ion Channels | Stroke | Traumatic brain injury | Alzheimer’s disease | Huntington’s disease | Amyotrophic lateral sclerosis | Retinal degeneration | Neuroprotectant