NMDAR-TRPM4 blocker C8 dihydrochloride - FMP-A-01 | Brophenexin

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3348

CAS [2243506-33-2]

MF C11H17BrN2.2HCl
MW 330.09

  • Purity: 99%
  • Soluble in water and DMSO
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NMDAR-TRPM4 blocker C8 dihydrochloride

Description

C8 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 2.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.

NMDAR-TRPM4 blocker C19 is available as Axon 3349.

KEYWORDS: C8 | supplier | NMDAR/TRPM4 inhibitor | FMP-A-01 | Brophenexin | CAS [2243506-33-2] | [1353979-43-7] | Glutamate | NMDA | Inhibitor | Ion Channels | Stroke | Traumatic brain injury | Alzheimer’s disease | Huntington’s disease | Amyotrophic lateral sclerosis | Retinal degeneration | Neuroprotectant

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Size Unit Price Stock
10 mg €120.00 In Stock
50 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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