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Indomethacin
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C19H16ClNO4
- MW: 357.79
Description
Indomethacin is a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes (COX-1 and COX-2). Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity.
More Information
| Parent CAS No. | 53-86-1 |
|---|---|
| Chemical Name | 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid |
| SMILES | C1(OC)C=C2C(CC(=O)O)=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C2=CC=1 |
| MFCD | MFCD00057095 |
| InChi | InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) |
| InChiKey | CGIGDMFJXJATDK-UHFFFAOYSA-N |
| CID | 3715 |
| Short Description | COX inhibitor |
References
- S Nalamachu S et al. Role of indomethacin in acute pain and inflammation management: a review of the literature. Postgrad Med. 2014 Jul;126(4):92-7.
- AL Blobaum et al. The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor. ACS Med Chem Lett. 2013 May 9;4(5):486-490.
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