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PAWI-2
- Soluble in DMSO
- MF: C19H21N3O3S
- MW: 371.45
Description
PAWI-2 is an inhibitor which targets both Wnt signaling (IC50 value of 11 nM) and ATM/p53 (EC50 value of 1.9 nM for p53). PAWI-2 binds tubulin and potently activates mitotic stress signaling to stabilize p53 and inhibit Wnt/β-catenin transactivation of downstream genes in colorectal cancer cells. Moreover, PAWI-2 inhibits cellular proliferation of androgen-sensitive and androgen-insensitive cells (LNCaP and PC-3, respectively).
More Information
| Parent CAS No. | 1448427-02-8 |
|---|---|
| Chemical Name | 1-(4-(4-Methyl-3,4-dihydroquinoxalin-1(2H)-ylsulfonyl)phenyl)pyrrolidin-2-one |
| SMILES | C1(N2CCCC2=O)C=CC(S(=O)(=O)N2C3C=CC=CC=3N(C)CC2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H21N3O3S/c1-20-13-14-22(18-6-3-2-5-17(18)20)26(24,25)16-10-8-15(9-11-16)21-12-4-7-19(21)23/h2-3,5-6,8-11H,4,7,12-14H2,1H3 |
| InChiKey | HKMFKYDGIJGBER-UHFFFAOYSA-N |
| CID | 89699521 |
| Short Description | Wnt/ATM/p53 inhibitor |
References
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