PAWI-2

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3152

CAS [1448427-02-8]

MF C19H21N3O3S
MW 371.45

  • Purity: 99%
  • Soluble in DMSO
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PAWI-2

Description

PAWI-2 is an inhibitor which targets both Wnt signaling (IC50 value of 11 nM) and ATM/p53 (EC50 value of 1.9 nM for p53). PAWI-2 binds tubulin and potently activates mitotic stress signaling to stabilize p53 and inhibit Wnt/β-catenin transactivation of downstream genes in colorectal cancer cells. Moreover, PAWI-2 inhibits cellular proliferation of androgen-sensitive and androgen-insensitive cells (LNCaP and PC-3, respectively).

KEYWORDS: PAWI-2 | supplier | Wnt/ATM/p53 inhibitor | PAWI2 | PAWI 2 | CAS [1448427-02-8] | ECM-adhesion | β-Catenin | Wnt | Inhibitor | Proteins | Prostate cancer | ATM

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5 mg €120.00 In Stock
25 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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