Alofanib - RPT835 | ES000835

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2930

CAS [1612888-66-0]

MF C19H15N3O6S
MW 413.40

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO
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Alofanib

Description

Alofanib is an allosteric inhibitor of FGFR2 and significantly inhibited bFGF-induced proliferation of HUVEC cells (IC50 value of 11 nM) and suppressed proliferation of SVEC-4-10 cells (IC50 value of 58 nM). Moreover, Alofanib suppressed the migration activity of endothelial cells, and their ability to form vessel-like structures in vitro. Also, Alofanib significantly decreased the number of microvessels in Matrigel implant and in ovarian cancer (SKOV-3) xenograft in vivo.

KEYWORDS: Alofanib | supplier | FGFR2 inhibitor | RPT835 | ES000835 | RPT 835 | RPT-835 | ES 000835 | ES-000835 | CAS [1612888-66-0] | FGF | FGFR | Inhibitor | Receptors | Ovarian cancer

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50 mg €300.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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