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Axon 2930
CAS [1612888-66-0]
MF C19H15N3O6SMW 413.40
Alofanib is an allosteric inhibitor of FGFR2 and significantly inhibited bFGF-induced proliferation of HUVEC cells (IC50 value of 11 nM) and suppressed proliferation of SVEC-4-10 cells (IC50 value of 58 nM). Moreover, Alofanib suppressed the migration activity of endothelial cells, and their ability to form vessel-like structures in vitro. Also, Alofanib significantly decreased the number of microvessels in Matrigel implant and in ovarian cancer (SKOV-3) xenograft in vivo.
KEYWORDS: Alofanib | supplier | FGFR2 inhibitor | RPT835 | ES000835 | RPT 835 | RPT-835 | ES 000835 | ES-000835 | CAS [1612888-66-0] | FGF | FGFR | Inhibitor | Receptors | Ovarian cancer
3-(N-(4-Methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid
[1612888-66-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!