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SNS 314 mesylate
- Parent CAS: 1057249-41-8
- Soluble in DMSO
- MF: C18H15ClN6OS2.CH4O3S
- MW: 527.04
Description
SNS 314 mesylate is a potent and selective Aurora kinase inhibitor with IC50 values of 9 nM, 31 nM and 3 nM for Aurora A, Aurora B and Aurora C, respectively. Moreover, SNS 314 mesylate displays significant activity in pre-clinical in vivo models.
More Information
| Parent CAS No. | 1057249-41-8 |
|---|---|
| Chemical Name | 1-(3-Chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea methanesulfonate |
| SMILES | C12SC=CC=1N=CN=C2NCCC1=CN=C(NC(NC2C=C(Cl)C=CC=2)=O)S1.CS(=O)(O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C18H15ClN6OS2.CH4O3S/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16;1-5(2,3)4/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26);1H3,(H,2,3,4) |
| InChiKey | FYCODPVDEFFWSR-UHFFFAOYSA-N |
| CID | 24995523 |
| Short Description | Aurora inhibitor |
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