SU11652

Based on 18 reference(s) in Google Scholar 8 10 18

Axon 2767

CAS [326914-10-7]

MF C22H27ClN4O2
MW 414.93

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

SU11652

Description

SU11652 is a sunitinib-like RTK inhibitor of PDGFR-β, VEGFR2, FGFR1 and FLT3, with IC50 values of 3, 27, 170 and 1.5 nM, respectively. Moreover, SU11652 inhibits cKit, acid sphingomyelinase, destabilizes lysosomes, and inhibits multidrug resistance.

AT Liao et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 2002 Jul 15;100(2):585-93.

L Sun et al. Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46(7):1116-9.

Y Guo et al. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 6;5:72.

AM Ellegaard et al. Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. Mol Cancer Ther. 2013 Oct;12(10):2018-30.

Angiogenesis Cell Signaling & Oncology FLT3 VEGFR PDGFR c-KIT RTK class III and IV; EC 2.7.10.1

Multi-targeted receptor tyrosine kinase inhibitor

Chemical name

(Z)-5-((5-chloro-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Parent CAS No.

[326914-10-7]

Order

Size	Unit Price	Stock
10 mg	€140.00	In Stock
50 mg	€490.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1128	Erlotinib hydrochloride	EGFR tyrosine kinase inhibitor	€70.00
1393	Gefitinib	EGFR tyrosine kinase inhibitor	€70.00
1394	Imatinib mesylate	Bcr-Abl, c-KIT and PDGFR kinase inhibitor	€60.00
1395	Lapatinib ditosylate	EGFR and ErbB-2/HER2 tyrosine kinase inhibitor	€80.00
1398	Sunitinib malate	Multi-targeted receptor tyrosine kinase inhibitor	€80.00
1411	Vandetanib	VEGFR and EGFR tyrosine kinase inhibitor	€50.00
1414	AG 013736	PDGFR,c-KIT and VEGFR tyrosine kinase inhibitor	€50.00
1415	CT 53518	PDGFR, c-KIT and FLT3 tyrosine kinase inhibitor	€70.00
1419	AB 1010	PDGFR, c-KIT and FGFR3 tyrosine kinase inhibitor	€70.00
1420	Pazopanib hydrochloride	PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor	€60.00
1433	CI 1033	EGFR tyrosine kinase inhibitor	€60.00
1461	Cediranib	VEGFR tyrosine kinase inhibitor	€70.00
1506	WZ 4002	EGFR kinase inhibitor (T790M specific)	€70.00
1526	Neratinib	EGFR and ErbB-2/HER2 tyrosine kinase inhibitor	€80.00
1544	BIBW 2992	EGFR and ErbB-2/HER2 tyrosine kinase inhibitor	€50.00
1547	OSI 930	c-Kit and VEGFR2 tyrosine kinase inhibitor	€90.00
1581	SU 11274	ATP-competitive inhibitor of c-MET	€90.00
1582	Foretinib	c-MET and VEGFR2 tyrosine kinase inhibitor	€90.00
1583	PF 04217903 mesylate	c-MET tyrosine kinase Inhibitor	€80.00
1632	OSI 420	EGFR tyrosine kinase inhibitor	€90.00
1637	Vatalanib	VEGFR tyrosine kinase inhibitor	€75.00
1638	ABT 869	PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor	€85.00
1653	AEE 788	EGFR, ErbB2 and VEGFR tyrosine kinase inhibitor	€80.00
1660	Crizotinib	c-MET Inhibitor; NPM-ALK inhibitor	€70.00
1662	CP 547632	VEGFR2 tyrosine kinase inhibitor	€70.00
1665	Pelitinib	EGFR tyrosine kinase inhibitor	€90.00
1678	Regorafenib	Multi-kinase RTK inhibitor	€70.00
1696	Quizartinib dihydrochloride	FLT3 inhibitor	€90.00
1717	Tivozanib	VEGFR1, 2, and 3 tyrosine kinase inhibitor	€80.00
1760	EGFR Inhibitor [879127-07-8]	Highly selective EGFR tyrosine kinase inhibitor	€120.00
1768	AMG 706	Multiple receptor tyrosine kinase inhibitor	€105.00
1819	Cabozantinib S-malate	Inhibitor of multiple receptor tyrosine kinases, specifically MET and VEGFR2	€60.00
1838	ARQ 197	c-MET tyrosine kinase Inhibitor	€90.00
1850	BMS 540215	Inhibitor of VEGFR (subtype 2 and 3 selective)	€110.00
1864	Brivanib alaninate	Prodrug of BMS 540215; Inhibitor of VEGF	€90.00
1891	SU 6668	Inhibitor of RTK targeting PDGFR, VEGF and FGFR	€100.00
1914	SGX 523	ATP-competitive inhibitor of c-MET	€120.00
1916	AMG 208	Inhibitor of c-MET receptor tyrosine kinase (RTK)	€95.00
1942	E 3810 dihydrochloride	Dual VEGFR/FGFR tyrosine kinase inhibitor	€90.00
1959	Golvatinib	Potent and orally available inhibitor of c-MET (HGFR) and VEGFR2	€90.00
1963	LY 573636	Anti-tumor agent; causes growth arrest and apoptosis	€80.00
1978	ZM 323881 hydrochloride	Inhibitor of VEGFR2	€105.00
1986	AST 1306 tosylate	ErbB2 and EGFR inhibitor	€90.00
1667	SU 5402	Fibroblast growth factor receptor (FGFR) inhibitor	€60.00
2368	Amuvatinib	RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met	€105.00
2501	Pexidartinib	Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3	€60.00
2648	Nintedanib	RTK inhibitor with antiangiogenic and antineoplastic activities	€70.00
2680	EAI045	Allosteric EGFR inhibitor (L858R/T790M-specific)	€105.00
2849	Apatinib	Inhibitor of VEGFR2	€120.00
2865	NVP-ACC789	Inhibitor of VEGFR2	€90.00
2837	BMS 605541	Potent, selective, orally active, and ATP-competitive VEGFR2 inhibitor	€90.00
3165	Lenvatinib	Multi-targeted receptor tyrosine kinase inhibitor	€70.00
3624	Toceranib phosphate	Multi-targeted receptor tyrosine kinase inhibitor	€60.00
3946	Altiratinib	Balanced inhibitor for MET, TIE2 (TEK), and VEGFR2 (KDR) kinases	Inquire
3969	Crenolanib	Selective small molecule inhibitor of PDGFRα, PDGFRβ and FLT3.	Inquire
3975	MGCD265 dihydrochloride	Orally active, potent MET/SMO dual inhibitor	€130.00
3998	MGCD516	Orally bioavailable receptor tyrosine kinase (RTK) inhibitor	Inquire
4073	CYC-116	Aurora kinases A & B and VEGFR2 inhibitor	Inquire

Customer Support

Customer Services

About Axon Medchem

Contact Us

SU11652

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

SU11652

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us