SU11652

Based on 18 reference(s) in Google Scholar 8 10 18

Axon 2767

CAS [326914-10-7]

MF C22H27ClN4O2
MW 414.93

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

SU11652

Description

SU11652 is a sunitinib-like RTK inhibitor of PDGFR-β, VEGFR2, FGFR1 and FLT3, with IC50 values of 3, 27, 170 and 1.5 nM, respectively. Moreover, SU11652 inhibits cKit, acid sphingomyelinase, destabilizes lysosomes, and inhibits multidrug resistance.

AT Liao et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 2002 Jul 15;100(2):585-93.

L Sun et al. Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46(7):1116-9.

Y Guo et al. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 6;5:72.

AM Ellegaard et al. Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. Mol Cancer Ther. 2013 Oct;12(10):2018-30.

Angiogenesis Cell Signaling & Oncology FLT3 VEGFR PDGFR c-KIT RTK class III and IV; EC 2.7.10.1

Multi-targeted receptor tyrosine kinase inhibitor

Chemical name

(Z)-5-((5-chloro-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Parent CAS No.

[326914-10-7]

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