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SP 141

Axon 2437
CAS:  1253491-42-7
Purity:  99%
  • Soluble in DMSO
  • MF:  C15H11N3O
  • MW:  249.27

Description

Specific MDM2 inhibitor (Ki value 28 nM in a FP-based MDM2 binding assay) with potent therapeutic effects in breast cancer models, regardless of p53 status. SP141 directly binds to MDM2, inhibits MDM2 expression and induces its autoubiquitination and proteasomal degradation.

More Information

Parent CAS No. 1253491-42-7
Chemical Name 6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole
SMILES N1C2=C(C=C(OC)C=C2)C2C=CN=C(C3=C4C(C=CC=C4)=CC=C3)C1=2
MFCD N.A.
InChi InChI=1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChiKey AABFWJDLCCDJJN-UHFFFAOYSA-N
CID 59620153
Short Description MDM2 inhibitor

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