PK-THPP

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2403

CAS [1332454-07-5]

MF C29H32N4O2
MW 468.59

  • Purity: 99%
  • Soluble in DMSO

PK-THPP

Description

Potent TASK-3 (KCNK9) antagonist (IC50 value 303 nM and 35nM for TASK-1 and TASK-3, respectively) with >140 fold selectivity over a wider range of potassium channels. PK-THPP produced a significant increase in active wake with a concurrent decrease in both REM and delta sleep immediately following administration to wild-type (WT) mice, and stimulated breathing by increasing tidal volume and breathing rate in isoflurane-anesthetized rats. PK-THPP induced a respiratory alkalosis and increased oxygenation.
Order
Size Unit Price Stock
10 mg €145.00 In Stock
50 mg €580.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...