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PK-THPP
- Soluble in DMSO
- MF: C29H32N4O2
- MW: 468.59
Description
More Information
| Parent CAS No. | 1332454-07-5 |
|---|---|
| Chemical Name | 1-(1-(6-(Biphenylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl)butan-1-one |
| SMILES | C(C1CCN(C2N=CN=C3CCN(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)CC3=2)CC1)(=O)CCC |
| MFCD | N.A. |
| InChi | InChI=1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3 |
| InChiKey | CJZGRIRZVHNUSM-UHFFFAOYSA-N |
| CID | 53464059 |
| Short Description | TASK-3 antagonist |
References
- D.P. Flaherty et al. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3968-73.
- C.A. Coburn et al. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem. 2012 Jan 2;7(1):123-33.
- J.F. Cotten. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr;116(4):810-6.
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