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ML 365
Axon 2840
CAS:
947914-18-3
Purity:
99%
- Soluble in DMSO
- MF: C22H20N2O3
- MW: 360.41
Description
ML365 is a potent and selective inhibitor of the two-pore-domain potassium channel TASK-1 (KCNK3/K2P3.1) with an IC50 value of 4 nM. Electrophysiological profiling showed approximately 62-fold selectivity over TASK-3.
By inhibiting the background potassium conductance generated by TASK-1, ML365 depolarizes responsive cells and alters membrane excitability. It is used in patch-clamp and functional studies of pulmonary vascular tone, respiratory control, cardiac electrophysiology and K2P channel gating.
Key Features
- Potent TASK-1/KCNK3 inhibitor
- IC50: 4 nM
- Approximately 62-fold selectivity over TASK-3
- Modulates background potassium conductance
Applications
- TASK-1 channel electrophysiology
- K2P channel pharmacology
- Membrane-excitability studies
- Pulmonary vascular research
- Respiratory and cardiac physiology
More Information
| Parent CAS No. | 947914-18-3 |
|---|---|
| Chemical Name | 2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide |
| SMILES | C1(C)C=C(C(=O)NC2C=CC=C(NC(=O)C3C(OC)=CC=CC=3)C=2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26) |
| InChiKey | UTAJHKSGYJSZBR-UHFFFAOYSA-N |
| CID | 46785920 |
| Short Description | TASK-1 inhibitor |
ML365
potent TASK-1/KCNK3 inhibitor
ML 365
ML-365
Potassium
TASK-1
K2P3.1
KCNK3
TASK-1/KCNK3
Inhibitor
TASK-1 channel electrophysiology
K2P channel pharmacology
Membrane-excitability studies
Pulmonary vascular research
Respiratory and cardiac physiology
cardiovascular research
vascular biology
receptor selectivity
enzyme pharmacology
drug discovery
CAS 947914-18-3
Axon Medchem
Axon 2840
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