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Desmethyl SCH 442416
- Soluble in DMSO
- MF: C19H17N7O2
- MW: 375.38
Description
Desmethyl SCH 442416 is a radioligand precursor for [11C]SCH442416 and a less potent adenosine receptor ligand than SCH 442416, with reported Ki values of 44 nM, 48 nM and 34 nM at A1, A2A and A3 receptors, respectively. It is used in the preparation and study of A2A receptor imaging ligands.
Adenosine A2A receptors are important CNS and immune-modulatory GPCR targets and are commonly investigated using radioligand binding and PET imaging tools. Desmethyl SCH 442416 supports adenosine receptor tracer development and comparative receptor-binding studies.
Key Features
- Precursor for [11C]SCH442416
- Adenosine receptor ligand with A1, A2A and A3 affinity
- Useful for PET radioligand development
- Related to selective A2A antagonist SCH 442416
Applications
- Adenosine receptor imaging research
- PET tracer precursor workflows
- A2A receptor binding studies
- CNS GPCR assay development
More Information
| Parent CAS No. | 188112-92-7 |
|---|---|
| Chemical Name | 4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenol |
| SMILES | C12N=C(N)N3N=C(C4OC=CC=4)N=C3C=1C=NN2CCCC1C=CC(O)=CC=1 |
| MFCD | MFCD12913317 |
| InChi | InChI=1S/C19H17N7O2/c20-19-23-17-14(18-22-16(24-26(18)19)15-4-2-10-28-15)11-21-25(17)9-1-3-12-5-7-13(27)8-6-12/h2,4-8,10-11,27H,1,3,9H2,(H2,20,23) |
| InChiKey | AXDUXMMFIPBLRQ-UHFFFAOYSA-N |
| CID | 10362099 |
| Short Description | A2A antagonist |
References
- K. Ishiwata et al. PET Tracers for mapping adenosine receptors as probes for diagnosis of CNS disorders. CNS Agents Med. Chem. 2007, 7, 55-57.
- Toddle et al. Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomography. J. Med. Chem. 2000, 43, 4359.
- A.K. Bhattacharjee et al. Striatal adenosine A2A receptor mediated PET Imaging in 6-hydroxydopamine lesioned rats using [18F]-MRS5425. Nucl. Med. Biol. 2011, 38, 897-906.
- B.A. Shinkre et al. Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists. Bioorg. Med. Chem. Lett. 2010, 20, 5690-5694.
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