Bulk Inquiry
Istradefylline
- KW6002
- Soluble in DMSO
- MF: C20H24N4O4
- MW: 384.43
Description
Istradefylline is a potent, selective and orally active adenosine A2A receptor antagonist used to reduce A2A-mediated inhibition of dopaminergic motor signaling.
A2A receptors are highly expressed in the striatum and functionally oppose dopamine D2 receptor pathways. Istradefylline is a clinically validated reference for Parkinson disease, basal-ganglia circuitry and adenosine–dopamine receptor interactions.
Key Features
- Selective adenosine A2A receptor antagonist
- Orally active CNS pharmacology
- Enhances dopaminergic motor-pathway output
- Clinically validated Parkinson disease mechanism
Applications
- A2A receptor binding and functional assays
- Parkinson disease and motor-circuit research
- Adenosine–dopamine receptor interaction studies
- Basal ganglia and striatal signaling models
More Information
| Parent CAS No. | 155270-99-8 |
|---|---|
| Chemical Name | (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione |
| SMILES | C1(=O)N(CC)C(=O)N(CC)C2N=C(/C=C/C3C=C(OC)C(OC)=CC=3)N(C)C1=2 |
| MFCD | MFCD00928421 |
| InChi | InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+ |
| InChiKey | IQVRBWUUXZMOPW-PKNBQFBNSA-N |
| CID | 5311037 |
| Short Description | A2A antagonist |
References
- S Shiozaki et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999, 147(1), 90-95.
- TN Chase et al. Translating A2A antagonist KW6002 from animal models to parkinsonian patients. Neurology 2003, 61(11 Suppl 6), S107-11.
- PA LeWitt et al. Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces "off" time in Parkinson's disease: a double-blind, randomized, multicenter clinical trial (6002-US-005). Ann. Neurol. 2008, 63(3), 295-302.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1188 | Adenosine amine congener |
From $137.50 |
| 1190 | 2-Chloroadenosine |
From $71.50 |
| 1193 | UK 432097 |
From $137.50 |
| 1253 | SCH 58261 |
From $99.00 |
| 1264 | SCH 442416 |
From $99.00 |
| 1265 | SDZ-WAG 994 |
From $137.50 |
| 1287 | GR 79236 |
From $132.00 |
| 1319 | CGS 21680 hydrochloride |
From $104.50 |
| 1603 | Rolofylline |
From $99.00 |
| 1851 | Rolofylline metabolite M1-trans |
From $115.50 |
| 1852 | Rolofylline metabolite M1-cis |
From $115.50 |
| 2076 | MRS 1523 |
From $143.00 |
| 2283 | Desmethyl SCH 442416 |
From $330.00 |
| 2289 | ABT 702 |
From $143.00 |
| 2317 | BAY 60-6583 |
From $143.00 |
| 3085 | CPI-444 |
From $93.50 |
| 3269 | PSB-KD107 |
From $154.00 |
| 3626 | Vipadenant |
From $99.00 |
| 3736 | CGS 15943 |
From $88.00 |
| 4001 | ZM241385 |
From $121.00 |
| 4069 | AZD4635 |
From Inquiry |
| 4132 | PBF-509 |
From $99.00 |
| 4377 | PSB-0777 ammonium salt |
From $165.00 |
| 4415 | PSB-0777 |
From $165.00 |
