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SCH 58261
- Soluble in DMSO
- MF: C18H15N7O
- MW: 345.36
Description
SCH 58261 is a highly potent and selective adenosine A2A receptor antagonist.
A2A receptors modulate cAMP signaling, striatal neurotransmission, inflammation and motor control. SCH 58261 is a reference antagonist for studying adenosine A2A receptor function in CNS, cardiovascular and immune pharmacology.
Key Features
- Highly selective A2A adenosine receptor antagonist
- Blocks ADORA2A-mediated cAMP signaling
- Useful for striatal and motor pathway studies
- Relevant to neurodegeneration and neuroinflammation research
Applications
- A2A receptor binding and functional assays
- Adenosine receptor pharmacology
- Parkinsonian pathway and motor control studies
- Neuroinflammation and immune signaling models
More Information
| Parent CAS No. | 160098-96-4 |
|---|---|
| Chemical Name | 2-Furan-2-yl-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine |
| SMILES | C12=NC(=NN1C(=NC1N(N=CC2=1)CCC1C=CC=CC=1)N)C1OC=CC=1 |
| MFCD | MFCD00933778 |
| InChi | InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22) |
| InChiKey | UTLPKQYUXOEJIL-UHFFFAOYSA-N |
| CID | 176408 |
| Short Description | A2A antagonist |
References
- P Popoli MD et al. Effects of SCH 58261, an Adenosine A2A Receptor Antagonist, on Quinpirole-Induced Turning in 6-Hydroxydopamine-Lesioned Rats: Lack of Tolerance after Chronic Caffeine Intake. Neuropsychopharmacol. 2000, 22, 522-529.
- C Zocchi et al. The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist. J. Pharmacol. Exp. Ther. 1996, 276(2), 398-404.
- Monopoli, A. et al. Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat. JPET, 1998, 285, 9-15.
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