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CGS 15943
- CGS15943 - CGS-15943
- Soluble in DMSO
- MF: C13H8ClN5O
- MW: 285.69
Description
CGS 15943 is a potent and selective adenosine receptor antagonist with Ki values of 3.5 nM, 4.2 nM, 16 nM and 51 nM for human A1, A2A, A2B and A3 receptors, respectively.
More Information
| Parent CAS No. | 104615-18-1 |
|---|---|
| Chemical Name | 9-Chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine |
| SMILES | C1C2N=C(N)N3N=C(C4=CC=CO4)N=C3C=2C=C(Cl)C=1 |
| MFCD | MFCD01529897 |
| InChi | InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16) |
| InChiKey | MSJODEOZODDVGW-UHFFFAOYSA-N |
| CID | 2690 |
| Short Description | Adenosine antagonist |
References
- M Williams et al. Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist. J Pharmacol Exp Ther. 1987 May;241(2):415-20.
- YC Kim et al. Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J Med Chem. 1996 Oct 11;39(21):4142-8.
- KN Klotz. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91.
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