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PBF-509
- NIR178 - Taminadenant
- Soluble in DMSO
- MF: C10H8BrN7
- MW: 306.12
Description
PBF-509 is a potent, selective and orally active A2A adenosine receptor antagonist with a Ki value of 12 nM.
More Information
| Parent CAS No. | 1337962-47-6 |
|---|---|
| Chemical Name | 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine |
| extra_info | Sold in collaboration with Chemietek |
| MFCD | N.A. |
| Short Description | A2A receptor antagonist |
References
- F Núñez et al. PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders. Front Pharmacol. 2018 Oct 19;9:1200.
- AA Chiappori et al. Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer. Clin Cancer Res. 2022 Jun 1;28(11):2313-2320.
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