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DPTN
Axon 3847
CAS:
224040-19-1
Purity:
99%
- Soluble in DMSO
- MF: C22H18N4OS
- MW: 386.47
Description
DPTN is a highly potent and moderately selective human and rat A3AR antagonist with Ki values of 0.36 nM and 1.6 nM for hA3AR and rA3AR receptors, respectively.
More Information
| Parent CAS No. | 224040-19-1 |
|---|---|
| Chemical Name | N-(4-(3,5-Dimethylphenyl)-5-(pyridin-4-yl)thiazol-2-yl)nicotinamide |
| SMILES | C1(C2C=CN=CC=2)SC(NC(=O)C2C=CC=NC=2)=NC=1C1C=C(C)C=C(C)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H18N4OS/c1-14-10-15(2)12-18(11-14)19-20(16-5-8-23-9-6-16)28-22(25-19)26-21(27)17-4-3-7-24-13-17/h3-13H,1-2H3,(H,25,26,27) |
| InChiKey | YDXZLBYHXZOWOC-UHFFFAOYSA-N |
| CID | 22282339 |
| Short Description | A3 antagonist |
References
- S Miwatashi et al. Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists. Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1126-37.
- ZG Gao et al. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic Signal. 2021 Dec;17(4):737-746.
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