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ABT 702
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C22H19BrN6O
- MW: 463.33
Description
ABT 702 is a potent, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 values of 2 nM in cytosolic assays and 50 nM in intact-cell assays. It is orally active in animal models of pain and inflammation and is used to study pharmacological elevation of endogenous adenosine tone.
Adenosine kinase regulates intracellular and extracellular adenosine availability, influencing purinergic signaling, inflammation and nociception. ABT 702 is useful for exploring ADK-dependent analgesic and anti-inflammatory mechanisms.
Key Features
- Potent non-nucleoside ADK inhibitor
- IC50: 2 nM in cytosolic assays
- Orally active in pain and inflammation models
- Increases adenosine pathway signaling by ADK inhibition
Applications
- Adenosine metabolism research
- Pain and inflammation model studies
- Purinergic signaling assays
- ADK inhibitor pharmacology
More Information
| Parent CAS No. | 214697-26-4 |
|---|---|
| Chemical Name | 5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine |
| SMILES | C1=NC(N)=C2C(C3=CC=CC(Br)=C3)=CC(C3=CC=C(N4CCOCC4)N=C3)=NC2=N1 |
| MFCD | MFCD05861333 |
| InChi | InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28) |
| InChiKey | RQCXKDWOCUJWQZ-UHFFFAOYSA-N |
| CID | 1973 |
| Short Description | ADK inhibitor |
References
- C.H. Lee et al. Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J Med Chem. 2001 Jun 21;44(13):2133-8.
- P.J. Hajduk et al. Design of adenosine kinase inhibitors from the NMR-based screening of fragments. J Med Chem. 2000 Dec 14;43(25):4781-6.
- M.F. Jarvis et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory... J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.
- E.A. Kowaluk et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory... J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.
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