ZD 9379

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2261

CAS [170142-20-8]

MF C19H14ClN3O4
MW 383.79

Purity: 100%
Soluble in 0.1N NaOH(aq) and DMSO

ZD 9379

Description

Selective antagonist of the glycine site on the NMDA receptor complex. ZD9379 crosses the blood-brain barrier and is neuroprotective. In vivo studies demonstrated reduced infarct size and less spreading depressions after treatment with ZD 9379.

T.M. Bare et al. Pyridazino[4,5-b]quinolinediones: novel glycine/N-methyl-D-aspartate antagonists for the treatment of stroke. J. Heterocyclic Chem. 1998, 35, 1171-1186.

T. Tatlisumak et al. A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta Neurochir. Suppl. 2000, 76, 331-333.

K. Takano et al. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 1997, 28, 1255-1262.

Antagonist of the glycine site on the NMDA receptor complex

Chemical name

7-chloro-2-(4-methoxy-2-methylphenyl)-2,3-dihydropyridazino[4,5-b]quinoline-1,4,10(5H)-trione

Parent CAS No.

[170142-20-8]

Order

Size	Unit Price	Stock
5 mg	€95.00	In Stock
25 mg	€335.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1156	Ifenprodil L-(+)-tartrate	NMDA antagonist	€55.00
1200	CNQX	AMPA/Kainate antagonist	€85.00
1201	DNQX	AMPA/Kainate antagonist	€50.00
1217	CFM 2	AMPA antagonist	€115.00
1246	Eliprodil	NMDA antagonist	€90.00
1249	N 20C hydrochloride	NMDA antagonist	€85.00
1262	Gavestinel	NMDA antagonist (glycine site)	€110.00
1312	YM 90K hydrochloride	AMPA antagonist	€85.00
1314	RO 25-6981 hydrochloride	NMDA NR2B antagonist	€110.00
1353	Lamotrigine	Glutamate antagonist; Na+ channel blocker	€60.00
1374	GYKI 53655	AMPA antagonist	€130.00
1406	CP 101606 mesylate	NMDA NR2B antagonist	€85.00
1434	RGH 896	NMDA NR2B antagonist	€95.00
1788	S 18986	Positive allosteric modulator of AMPA receptor	€105.00
2079	CMPDA	Positive allosteric modulator of AMPA receptor	€85.00
2254	CP 101606	NMDA NR2B antagonist	€120.00
2601	RO 25-6981 maleate	NMDA NR2B antagonist	€110.00
2708	TCN-201	NMDA NR2A antagonist	€105.00
3335	AZD6765 dihydrochloride	Noncompetitive NMDA antagonist	€90.00
3348	NMDAR-TRPM4 blocker C8 dihydrochloride	NMDAR/TRPM4 interaction interface inhibitor	€120.00
3349	NMDAR-TRPM4 blocker C19 dihydrochloride	NMDAR/TRPM4 interaction interface inhibitor	€130.00
3472	NMDA	Selective NMDA agonist	€60.00
3841	Dextromethorphan hydrobromide	Noncompetitive NMDA receptor antagonist	€60.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

ZD 9379

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

ZD 9379

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us