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ZD 9379
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C19H14ClN3O4
- MW: 383.79
Description
More Information
| Parent CAS No. | 170142-20-8 |
|---|---|
| Chemical Name | 7-chloro-2-(4-methoxy-2-methylphenyl)-2,3-dihydropyridazino[4,5-b]quinoline-1,4,10(5H)-trione |
| SMILES | N1C2=C(C=CC(Cl)=C2)C(=O)C2C(=O)N(C3=CC=C(OC)C=C3C)NC(=O)C1=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H14ClN3O4/c1-9-7-11(27-2)4-6-14(9)23-19(26)15-16(18(25)22-23)21-13-8-10(20)3-5-12(13)17(15)24/h3-8H,1-2H3,(H,21,24)(H,22,25) |
| InChiKey | PSTDMIAVUUYOOQ-UHFFFAOYSA-N |
| CID | 9843028 |
| Short Description | NMDA antagonist |
References
- T.M. Bare et al. Pyridazino[4,5-b]quinolinediones: novel glycine/N-methyl-D-aspartate antagonists for the treatment of stroke. J. Heterocyclic Chem. 1998, 35, 1171-1186.
- T. Tatlisumak et al. A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta Neurochir. Suppl. 2000, 76, 331-333.
- K. Takano et al. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 1997, 28, 1255-1262.
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