AZD2858 hydrochloride

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2194

CAS [2108876-05-5]

MF C21H23N7O3S.HCl
MW 489.98

  • Purity: 98%
  • Soluble in water and DMSO

AZD2858 hydrochloride


Potent and highly selective Glycogen Synthase Kinase-3β (GSK-3β; Ki value 4.9 nM) inhibitor for Alzheimer’s disease with good BBB permeability in a bovine endothelial cell assay. AZD2858 inhibits GSK-3β-mediated tau phosphorylation (IC50 value 76 nM) in vitro, and shows a good overall selectivity versus a panel of 26 kinases and >100 fold selectivity over CDK2 (Ki value 540 nM).In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass by GSK-3 mediated inhibition of Wnt canonical signaling, making AZD2858 a possible therapeutic candidate for osteoporosis. The free base AZD2858 is available as Axon 3771.

KEYWORDS: AZD2858 hydrochloride | GSK3â inhibitor | GSK3 | GSK-3 | AZD-2858 | AZD-2858 | Wnt | osteoporosis | Alzheimer's | AD | amyloid | tau | CDK2 | glycogen | synthase

Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €330.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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