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SC 236
- SC 58236
- Soluble in DMSO
- MF: C16H11ClF3N3O2S
- MW: 401.79
Description
Selective COX-2 inhibitor, which showed an impressive selectivity for COX-2 over COX-1 (IC50 0.01 µM vs. 17.8 µM respectively); NSAID and early lead compound during the discovery of Celecoxib (Axon 1919). However, SC236 showed an extremely long plasma half-life, not preferred for further development as potential therapeutic
More Information
| Parent CAS No. | 170569-86-5 |
|---|---|
| Chemical Name | 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide |
| extra_info | . |
| SMILES | C1(C2C=CC(Cl)=CC=2)N(C2=CC=C(S(N)(=O)=O)C=C2)N=C(C(F)(F)F)C=1 |
| MFCD | MFCD00941297 |
| InChi | InChI=1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25) |
| InChiKey | NSQNZEUFHPTJME-UHFFFAOYSA-N |
| CID | 9865808 |
| Short Description | COX-2 inhibitor |
References
- TD Penning et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene (...). J. Med. Chem. 1997, 40(9), 1347-1365.
- A Planagumà et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARγ activation. FASEB J. 2005, 19(9), 1120-1122.
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