SC 236 - SC 58236

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2108

CAS [170569-86-5]

MF C16H11ClF3N3O2S
MW 401.79

Purity: 99%
Soluble in DMSO

SC 236

Description

Selective COX-2 inhibitor, which showed an impressive selectivity for COX-2 over COX-1 (IC50 0.01 µM vs. 17.8 µM respectively); NSAID and early lead compound during the discovery of Celecoxib (Axon 1919). However, SC236 showed an extremely long plasma half-life, not preferred for further development as potential therapeutic

TD Penning et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene (...). J. Med. Chem. 1997, 40(9), 1347-1365.

A Planagumà et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARγ activation. FASEB J. 2005, 19(9), 1120-1122.

Selective COX-2 inhibitor

Chemical name

4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Parent CAS No.

[170569-86-5]

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50 mg	€260.00	In Stock

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Axon ID	Name	Description
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SC 236 - SC 58236

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SC 236 - SC 58236

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