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Hesperadin
- Soluble in DMSO
- MF: C29H32N4O3S
- MW: 516.65
Description
Hesperadin is a rapid, reversible and ATP-competitive Aurora B kinase inhibitor. It disrupts Aurora B-dependent mitotic processes including chromosome alignment, spindle checkpoint control and cytokinesis.
Aurora B is a chromosomal passenger complex kinase required for accurate chromosome segregation and cell division. Hesperadin is useful for studying mitotic defects, aneuploidy mechanisms and Aurora B pharmacology in proliferating cells.
Key Features
- Reversible ATP-competitive Aurora B inhibitor
- Rapidly disrupts mitotic kinase signaling
- Modulates chromosome segregation and cytokinesis
- Useful cell-cycle pharmacology tool
Applications
- Aurora B kinase assays
- Mitotic checkpoint studies
- Chromosome segregation research
- Cancer cell-cycle model profiling
More Information
| Parent CAS No. | 422513-13-1 |
|---|---|
| Chemical Name | (Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide |
| SMILES | C(S(NC1C=CC2=C(C=1)/C(=C(C1=CC=CC=C1)/NC1=CC=C(CN3CCCCC3)C=C1)/C(=O)N2)(=O)=O)C |
| MFCD | MFCD18074526 |
| InChi | InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27- |
| InChiKey | GLDSKRNGVVYJAB-DQSJHHFOSA-N |
| CID | 135421442 |
| Short Description | Aurora B inhibitor |
References
- S Hauf et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 2003, 16192), 281.
- F Sessa et al. Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol. Cell, 2005, 18(3), 379.
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