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TDZD 8
- Soluble in DMSO
- MF: C10H10N2O2S
- MW: 222.26
Description
More Information
| Parent CAS No. | 327036-89-5 |
|---|---|
| Chemical Name | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
| SMILES | S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C |
| MFCD | MFCD04973552 |
| InChi | InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3 |
| InChiKey | JDSJDASOXWCHPN-UHFFFAOYSA-N |
| CID | 4124851 |
| Short Description | GSK-3β inhibitor |
References
- AA Martinez et al.First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J. Med. Chem. 2002, 45(6), 1292-1299.
- M Collino et al. Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. Shock. 2008, 30(3), 299-307.
- D Aguilar-Morante et al. Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8. PLoS ONE 2010, 5(11), e13879.
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