Bulk Inquiry
PRT 4165
- NSC 600157
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C15H9NO2
- MW: 235.24
Description
More Information
| Parent CAS No. | 31083-55-3 |
|---|---|
| Chemical Name | 2-(pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione |
| SMILES | C1(=O)C2=C(C=CC=C2)C(=O)/C/1=CC1=CC=CN=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H |
| InChiKey | OMHZFEWYVFWVLI-UHFFFAOYSA-N |
| CID | 207893 |
| Short Description | Bmi1/Ring1A inhibitor |
References
- I Alchanati et al. The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target. PLoS One. 2009, 4(12), e8104.
- L Bedford et al. Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets. Nat. Rev. Drug Discov. 2011, 10, 29-46.
- IH Ismail et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4442 | iBP |
From $165.00 |
| 1129 | BI 2536 |
From $99.00 |
| 1131 | GW 843682X |
From $93.50 |
| 1473 | BI 6727 |
From $99.00 |
| 1530 | RO 3306 |
From $88.00 |
| 1538 | JNJ 26854165 |
From $115.50 |
| 1585 | Nutlin-3 |
From $104.50 |
| 1586 | JNJ 26854165 dihydrochloride |
From $115.50 |
| 1597 | Aurora A inhibitor I |
From $137.50 |
| 1625 | GSK579289A |
From $121.00 |
| 1626 | GSK 461364 analogue II |
From $143.00 |
| 1630 | Aurora A inhibitor II |
From $137.50 |
| 1643 | HLI 373 |
From $143.00 |
| 1688 | GSK 461364 |
From $115.50 |
| 1880 | Nutlin-3a |
From $104.50 |
| 1881 | Nutlin-3b |
From $99.00 |
| 1904 | SMER 3 |
From $99.00 |
| 1910 | MLN0905 |
From $104.50 |
| 1961 | MK 5108 |
From $121.00 |
| 2003 | MLN8237 |
From $99.00 |
| 2008 | Tenovin 1 |
From $77.00 |
| 2009 | RITA |
From $115.50 |
| 2164 | SJ 172550 |
From $104.50 |
| 2249 | Tenovin 6 |
From $115.50 |
