PRT 4165 - NSC 600157

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1953

CAS [31083-55-3]

MF C15H9NO2
MW 235.24

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

PRT 4165

Description

E3 Ubiquitin ligase Bmi1/Ring1A inhibitor. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro.

I Alchanati et al. The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target. PLoS One. 2009, 4(12), e8104.

L Bedford et al. Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets. Nat. Rev. Drug Discov. 2011, 10, 29-46.

IH Ismail et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54.

E3 Ubiquitin ligase Bmi1/Ring1A inhibitor

Chemical name

2-(pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione

Parent CAS No.

[31083-55-3]

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PRT 4165 - NSC 600157

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