XMD 8-92

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1846

CAS [1234480-50-2]

MF C26H30N6O3
MW 474.55

Purity: 99%
Soluble in DMSO

XMD 8-92

Description

Potent and selective inhibitor of big MAP kinase 1 (BMK1/ERK5).

Note: XMD 8-92 is also available as water soluble TFA-salt (Axon 1621)

Q. Yang et al. Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein. Cancer Cell, 2010, 18(3), 258-267.

Q Yang and JD Lee. Targeting the BMK1 MAP Kinase Pathway in Cancer Therapy.
Clin. Cancer Res. 2011, 17, 3527-3532.

BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.

BMK1 inhibitor; ERK5 inhibitor

Chemical name

2-(2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one

Source information

Sold under agreement with the Dana-Faber Cancer Institute

Parent CAS No.

[1234480-50-2]

Order

Size	Unit Price	Stock
2 mg	€70.00	In Stock
5 mg	€95.00	In Stock
25 mg	€295.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€460.00	In Stock

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XMD 8-92

Description

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Parent CAS No.

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XMD 8-92

Description

Chemical name

Source information

Parent CAS No.

Related Products

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