MK 2206 dihydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1684

CAS [1032350-13-2]

MF C25H21N5O.2HCl
MW 480.39

Purity: 99%
Soluble in water and DMSO

MK 2206 dihydrochloride

Description

An orally potent and highly selective non-ATP-competitive allosteric Akt inhibitor that has nanomolar IC50 values and broad preclinical anti-tumor activities.

H Hirai et al. MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo. Mol. Cancer Ther. 2010, 9(7), 1956-1967.

AW Tolcher et al. A phase I study of MK-2206, an oral potent allosteric Akt inhibitor (Akti), in patients (pts) with advanced solid tumor (ST). J. Clin. Oncol. 27:15s, 2009 (suppl; abstr 3503).

R Liu et al. The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway. J. Clin. Endocrinol. Metab. 2011, 96(4), E577-E585.

Akt inhibitor (allosteric)

Chemical name

8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

Parent CAS No.

[1032349-93-1]

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Size	Unit Price	Stock
5 mg	€80.00	In Stock
25 mg	€280.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€120.00	In Stock
2 x 25 mg	€440.00	In Stock

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MK 2206 dihydrochloride

Description

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MK 2206 dihydrochloride

Description

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