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MK 2206 dihydrochloride
- Parent CAS: 1032349-93-1
- Soluble in water and DMSO
- MF: C25H21N5O.2HCl
- MW: 480.39
Description
MK 2206 dihydrochloride is a potent, highly selective, non-ATP-competitive allosteric Akt inhibitor with nanomolar activity against Akt isoform signaling.
Akt integrates PI3K pathway inputs controlling survival, metabolism and growth. MK 2206 is a reference compound for studying allosteric Akt inhibition, pathway feedback and tumor cell dependence on PI3K/Akt signaling.
Key Features
- Allosteric inhibitor of Akt kinase signaling
- Non-ATP-competitive mechanism
- Nanomolar activity in Akt pathway assays
- Broad preclinical antitumor pathway relevance
Applications
- PI3K/Akt pathway research
- Cancer cell survival and proliferation studies
- Kinase signaling feedback assays
- Combination therapy mechanism studies
More Information
| Parent CAS No. | 1032349-93-1 |
|---|---|
| Chemical Name | 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride |
| SMILES | C12=NNC(=O)N1C=CC1N=C(C3C=CC(C4(N)CCC4)=CC=3)C(C3C=CC=CC=3)=CC=12.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C25H21N5O.2ClH/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31;;/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31);2*1H |
| InChiKey | HWUHTJIKQZZBRA-UHFFFAOYSA-N |
| CID | 46930998 |
| Short Description | Akt inhibitor |
References
- H Hirai et al. MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo. Mol. Cancer Ther. 2010, 9(7), 1956-1967.
- AW Tolcher et al. A phase I study of MK-2206, an oral potent allosteric Akt inhibitor (Akti), in patients (pts) with advanced solid tumor (ST). J. Clin. Oncol. 27:15s, 2009 (suppl; abstr 3503).
- R Liu et al. The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway. J. Clin. Endocrinol. Metab. 2011, 96(4), E577-E585.
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