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CP 547632
- Soluble in DMSO
- MF: C20H24BrF2N5O3S
- MW: 532.4
Description
A potent and oral tyrosine kinase inhibitor (TKI), targeting VEGFR2 and basic FGF kinases (IC50 to be 11 and 9 nM respectively); selective relative to EGFR, PDGF-ß, and other related TKs; inhibits VEGF-stimulated autophosphorylation of VEGFR2 in a whole cell assay with an IC50 value of 6 nM.
More Information
| Parent CAS No. | 252003-65-9 |
|---|---|
| Chemical Name | 3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide |
| SMILES | C1(Br)C=C(F)C(COC2C(C(=O)N)=C(NC(=O)NCCCCN3CCCC3)SN=2)=C(F)C=1 |
| MFCD | MFCD07772279 |
| InChi | InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30) |
| InChiKey | HXHAJRMTJXHJJZ-UHFFFAOYSA-N |
| CID | 9811611 |
| Short Description | VEGFR2 inhibitor |
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